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Updated: Apr 26, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
High mobility group box 1 protein (HMGB-1): a pathogenic role in preeclampsia?
P-A Pradervand1, S Clerc2, J Frantz2
1Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland; Département de Gynécologie-obstétrique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
Abstract:
We evaluated whether preeclampsia is associated with elevated circulating levels of High mobility group box 1 protein (HMGB-1), a nuclear protein with proinflammatory effects when released extracellularly. We enrolled 48 women, 32 in third trimester pregnancy (16 with, 16 without preeclampsia), and 16 healthy non pregnant. In the peripheral blood of pregnant women, HMGB-1 concentration was assessed serially, before and after delivery. With or without preeclampsia, third trimester pregnancy was associated with elevated levels of HMGB-1. This elevation is exaggerated in preeclampsia. The source of HMGB-1 observed in these conditions is likely to involve tissues other than the placenta itself.
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