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Updated: Apr 26, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Temporal patterns of drug-eluting stent failure and its relationship with clinical outcomes
Cheol Whan Lee1, Jung-Min Ahn, Sung-Han Yoon
1Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Objectives:
We investigated the temporal patterns of drug-eluting stents (DES) failure and its relationship with clinical outcomes in patients with DES failure.
Background:
Time to DES failure is widely variable, but little information is available on the temporal patterns of DES failure and its impact on clinical outcomes.
Methods:
The angiographic patterns of DES failure and clinical outcomes in 633 patients with 676 lesions who presented with their first instance of DES failure were analyzed. The primary outcome was all-cause death following treatment for DES failure.
Results:
DES failure occurred in a median of 10.1 months after the index procedure. We identified 548 and 85 instances of DES restenosis (86.6%) and stent thrombosis (13.4%), respectively. Patients were divided into three groups according to the interval from the index procedure to DES failure: group 1 (early DES failure: <12 months), group 2 (late: 12-36 months), and group 3 (very late: ≥36 months). Acute myocardial infarction was more common in patients who developed failure after ≥12 months than patients with earlier presentations. Focal DES failure was more common in group 1, whereas nonfocal DES failure in groups 2 and 3. During follow-up after retreatment (median, 52.8 months), all-cause death was significantly higher in group 3 compared with group 1 (adjusted hazard ratio, 2.97; 95%CI, 1.31-6.74; P = 0.009). Similar findings were observed in terms of the rates of death or myocardial infarction.
Conclusions:
Late DES failure is more likely to progress to acute myocardial infarction, aggressive angiographic patterns, and worse outcomes following retreatment.
