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Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets
Peng Zhao1, Zitian Chen, Yizhou Li
1College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 (China).
Abstract:
The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.
