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Updated: Apr 26, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus
Jennifer Fishovitz1, Juan A Hermoso, Mayland Chang
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Abstract:
High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.
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