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Induction of mixed function oxidase activities of protein A in rat mammary tumors
M R Bansal1, D Khanna, K G Gupta
1Department of Biophysics, Panjab University, Chandigarh, India.
Carcinogenesis
|September 1, 1989
Abstract:
Following s.c. administration of purified protein A, to 7,12-dimethylbenz(alpha)anthracene-induced mammary-tumor-bearing rats, a regenerated metabolism of the carcinogen was observed. The antitumor effect of protein A was evident from the decrease in tumor volume. The phase I and phase II enzyme activities suggest that protein A has the ability to induce the mixed function oxidases activity, which are active in the metabolism of xenobiotics.