Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.3K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.3K
Preclinical Development: Overview01:28

Preclinical Development: Overview

4.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.7K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.9K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.9K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.9K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.9K
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

541
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
541

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tales of total synthesis.

Nature reviews. Chemistry·2026
Same author

A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations.

Journal of the American Chemical Society·2022
Same author

A Highly Convergent Total Synthesis of Norhalichondrin B.

Journal of the American Chemical Society·2021
Same author

Corrigendum: The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies.

Angewandte Chemie (International ed. in English)·2021
Same author

Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.

Proceedings of the National Academy of Sciences of the United States of America·2021

Related Experiment Video

Updated: Apr 26, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

6.4K

Advancing the drug discovery and development process.

K C Nicolaou1

  • 1Department of Chemistry, Rice University, 6100 Main Street, Houston, TX 77005 (USA). kcn@rice.edu.

Angewandte Chemie (International Ed. in English)
|July 22, 2014
PubMed
Summary

This essay explores advancements in drug discovery and development by leveraging chemistry and biology. It aims to inspire future scientists and foster academic-industry collaborations for creating novel medicines.

Keywords:
academic-industrial partnershipsbiological assaysbiological targetsdrug designorganic synthesis

More Related Videos

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

12.8K

Related Experiment Videos

Last Updated: Apr 26, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

6.4K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

12.8K

Area of Science:

  • Drug discovery and development
  • Medicinal chemistry
  • Biotechnology

Background:

  • Current drug discovery and development processes are complex and evolving.
  • Significant progress in fundamental knowledge and technical expertise in chemistry and biology offers new opportunities.

Purpose of the Study:

  • To summarize the current state of drug discovery and development.
  • To highlight opportunities presented by advances in chemistry and biology.
  • To inspire students and academics to pursue careers in drug discovery and development.
  • To encourage multidisciplinary partnerships between academia and industry.

Main Methods:

  • Review of current knowledge and technical capabilities in chemistry and biology.
  • Discussion of strategies to leverage these advancements for drug discovery.
  • Emphasis on fostering interdisciplinary collaboration.

Main Results:

  • Identification of key areas where fundamental knowledge and technical know-how can be applied.
  • Highlighting the potential for breakthroughs in medicine invention.
  • Demonstrating the value of merging complementary expertise.

Conclusions:

  • Drug discovery and development can be significantly advanced by integrating knowledge from chemistry, biology, and medicine.
  • Multidisciplinary collaboration is crucial for innovation and addressing unmet medical needs.
  • Inspiring the next generation of scientists is vital for future progress.