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Updated: Apr 26, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Importance of the 6'-hydroxy group and its configuration for apramycin activity
Appi Reddy Mandhapati1, Dimitri Shcherbakov, Stefan Duscha
1Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202 (USA).
Abstract:
A series of apramycin derivatives was prepared and investigated for antibacterial activity and the ability to inhibit protein synthesis in cell-free translation assays. The effect of various modifications at the 6'- and N7'-positions on antiribosomal activity is discussed in terms of their influence on drug binding to specific residues in the decoding A-site. These studies contribute to the development of a structure-activity relationship for the antibacterial activity of the apramycin class of aminoglycosides and to the future design and development of more active and less toxic antibiotics.
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