Related Experiment Videos
Experimental model of varicocele.
A Shafik1, M A Wali, Y E Abdel Azis
1Department of Surgery, Faculty of Medicine and Veterinary Medicine, Cairo and Menofia University, Egypt.
European Urology
|January 1, 1989
Summary
This study successfully created a canine varicocele model, revealing significant testicular temperature increases and hormonal imbalances. Induced varicocele led to decreased sperm counts and testicular degeneration, impacting male fertility.
Area of Science:
- Urology
- Reproductive Medicine
- Animal Models
Background:
- Varicocele, a common cause of male infertility, affects testicular physiology.
- Animal models are crucial for understanding varicocele-induced pathophysiology.
Purpose of the Study:
- To develop a canine model of varicocele.
- To investigate the physiological and histological changes in the testes following varicocele induction.
Main Methods:
- A varicocele model was created in 17 dogs by excising a strip of the spermatic cord's fasciomuscular tube.
- Control dogs (5) underwent sham surgery.
- Testicular temperature, semen quality, and serum hormone levels (testosterone, FSH, LH, prolactin) were assessed.
Main Results:
- Manifest varicocele developed in 16/17 test dogs, with significant testicular temperature elevation.
- Semen analysis showed decreased sperm counts in most affected dogs.
- Histological examination revealed varicocele and degenerative changes in testes, including contralateral effects.
- Serum testosterone decreased, and prolactin increased post-surgery.
Conclusions:
- The canine model effectively replicates varicocele-induced testicular alterations.
- Induced varicocele negatively impacts sperm production and testicular histology.
- Hormonal changes, specifically reduced testosterone and increased prolactin, are associated with induced varicocele.