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Updated: Apr 26, 2026
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Wide-field multiplexed imaging of EGFR-targeted cancers using topical application of NIR SERS nanoprobes
Rupananda J Mallia1, Patrick Z McVeigh, Carl J Fisher
1Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Aim:
As the possibilities of molecular imaging in personalized medicine evolve rapidly, the optical advantages of extremely narrow and intense spectral bands makes surface-enhanced Raman scattering (SERS) an appealing candidate for multiplexed recognition of targeted biomarkers over other optical imaging modalities.
Materials & Methods:
In this proof-of-concept study, we report wide-field Raman detection of lung cancer using multimodal SERS nanoprobes specific to the EGF receptor family, both in vitro and in vivo.
Results:
For the first time, we demonstrate wide-field multiplexed Raman imaging for cancer detection in vivo after topical application of a 'cocktail' of SERS nanoprobes.
Conclusion:
This advancement represents a key step towards sensitive wide-field Raman endoscopic imaging of multiple biomarkers for early and accurate diagnosis of EGF receptor-expressing tumors of different internal organs.
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