Nanomedicine scale-up technologies: feasibilities and challenges
Rishi Paliwal1, R Jayachandra Babu, Srinath Palakurthi
1Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, 1010 West Avenue B, MSC 131, Kingsville, Texas, 78363, USA.
AAPS Pharmscitech
|July 23, 2014
Summary
Nanomedicine utilizes nanoparticles for targeted drug delivery and early disease diagnosis. This review covers nanoparticle development, scale-up, and commercialization challenges, focusing on polymeric and lipid nanoparticles.
Area of Science:
- Biomedical Engineering
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Nanomedicine leverages nanosized particles for advanced drug delivery and diagnostics.
- These nanoparticles offer unique properties for targeted therapeutic and diagnostic applications.
- Theranostic applications combine therapeutic and diagnostic capabilities within a single nanodevice.
Purpose of the Study:
- To review recent advancements in nanoparticle development methods.
- To focus on polymeric and lipid nanoparticles for therapeutic applications.
- To discuss challenges in scaling up nanoparticle production and commercialization.
Main Methods:
- Review of current literature on nanoparticle formulation.
- Analysis of scale-up techniques for nanoparticle manufacturing.
- Examination of regulatory and commercialization hurdles.
Main Results:
- Nanoparticle characteristics (size, surface, loading, targeting) are crucial for efficacy.
- Polymeric and lipid nanoparticles are key platforms for nanomedicine development.
- Significant challenges exist in scaling up production and achieving commercial viability.
Conclusions:
- Continued research is needed to overcome formulation and scale-up challenges.
- Addressing regulatory pathways is essential for nanomedicine commercialization.
- Nanomedicine holds significant promise for future healthcare solutions.
