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The freestyle aortic bioprosthesis: a systematic review.
Andrew G Sherrah1, J James B Edelman2, Shane R Thomas3
1Sydney Medical School, University of Sydney, Australia; The Baird Institute, Royal Prince Alfred Hospital, Sydney, Australia.
Heart, Lung & Circulation
|July 23, 2014
Summary
The Medtronic Freestyle bioprosthesis (FSB) offers comparable outcomes to other aortic valve prostheses, showing similar survival rates and reduced left ventricular mass. Post-operative results for FSB implantation are robust in both short and long terms.
Area of Science:
- Cardiovascular Surgery
- Bioprosthetic Devices
- Aortic Valve Replacement
Background:
- The Medtronic Freestyle bioprosthesis (FSB) is an alternative for aortic valve and aortic root surgery.
- Systematic review of post-operative outcomes following FSB implantation for aortic disease.
Purpose of the Study:
- To systematically review post-operative outcomes of the Medtronic Freestyle bioprosthesis (FSB).
- Compare FSB performance against alternative aortic prostheses.
Main Methods:
- Systematic review of randomized studies and case series.
- Inclusion criteria: prospective randomized studies comparing FSB with alternatives; case series with ≥100 patients.
Main Results:
- FSB showed comparable hospital mortality (4.5% vs. 5.3%) and 8-year survival (80±5.0% vs. 77±6.0%) versus homografts.
- Comparable reduction in left ventricular mass index observed.
- Case series (n>6000) showed weighted mean operative mortality 5.2%, neurological event rate 5.5%, and 5-year survival 77.8%.
Conclusions:
- FSB demonstrates comparable performance to alternative prostheses regarding mortality and survival.
- FSB implantation leads to comparable reduction in left ventricular mass index.
- Case series confirm robust short- and long-term post-operative outcomes for FSB.
