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Coronary triglyceride deposition in contemporary advanced diabetics

Yoshihiko Ikeda1, Nobuhiro Zaima, Ken-ichi Hirano

  • 1Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

Pathology International
|July 23, 2014
PubMed

Insights

Advanced diabetes mellitus is linked to increased triglyceride deposit cardiomyovasculopathy (TGCV), characterized by abnormal fat accumulation in coronary arteries and heart muscle. This study investigated TG deposition in autopsied diabetic hearts, revealing significant arterial TG accumulation in diabetic subjects.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Pathology

Background:

  • Diabetic heart diseases, including heart failure and coronary artery disease, require further pathophysiological clarification.
  • A novel phenotype, triglyceride deposit cardiomyovasculopathy (TGCV), involves aberrant triglyceride (TG) accumulation in coronary arteries and myocardium.
  • Previous findings were based on a single cardiac transplant recipient.

Purpose of the Study:

  • To investigate TG deposition in the cardiovasculature of autopsied individuals with advanced diabetes mellitus (DM).
  • To compare TG levels and distribution in coronary arteries between diabetic and non-diabetic subjects.
  • To explore the association between TG deposition and advanced DM.

Main Methods:

  • Examination of autopsied hearts from 20 advanced DM subjects (DMG) and 20 age/sex-matched non-diabetic controls (NDMG).
  • Biochemical measurement of tissue TG content.
  • Imaging Mass Spectrometry for spatial TG distribution analysis in coronary arteries.

Main Results:

  • Coronary arterial TG content was significantly higher in the DM group compared to the non-DM group.
  • TG deposition in coronary arteries was primarily observed in smooth muscle cells.
  • All DMG subjects had heart diseases, with 14 exhibiting multi-vessel coronary artery disease.

Conclusions:

  • Abundant TG deposition in coronary arteries is associated with advanced diabetes mellitus.
  • The findings support the concept of TGCV in a broader diabetic population.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications of TG deposition in diabetic cardiovascular disease.

Keywords:
atherosclerosiscongestive heart failurecoronary artery diseasediabetes mellitustriglyceride

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