Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

3.7K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
3.7K
Centrosome Duplication02:25

Centrosome Duplication

2.5K
2.5K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

6.8K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
6.8K
Interphase00:54

Interphase

176.5K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
176.5K
Interphase00:56

Interphase

12.6K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
12.6K
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

221.6K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
221.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1.

Nature communications·2026
Same author

Molecular architecture of the ciliary base in mammalian multiciliated cells.

bioRxiv : the preprint server for biology·2026
Same author

PRECLINICAL ACTIVITY OF THE B7-H3- TARGETING ANTIBODY-DRUG CONJUGATE (ADC) VOBRAMITAMAB DUOCARMAZINE (VOBRA DUO) IN PEDIATRIC SOLID TUMORS.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models.

International journal of molecular sciences·2026
Same author

The luminal ring protein C2CD3 acts as a radial in-to-out organizer of the distal centriole and appendages.

PLoS biology·2025
Same author

Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi.

Molecular biology of the cell·2025

Related Experiment Video

Updated: Apr 26, 2026

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

19.6K

The centriole duplication cycle.

Elif Nur Fırat-Karalar1, Tim Stearns2

  • 1Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|July 23, 2014
PubMed
Summary

Centriole duplication is tightly regulated by specific factors and cell cycle progression. This review explores new models for centriole assembly and number control, including variations like deuterosomes and blepharoplasts.

Keywords:
blepharoplastcentriolecentrosomedeuterosome

More Related Videos

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

14.8K
Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles
10:38

Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles

Published on: September 21, 2018

11.7K

Related Experiment Videos

Last Updated: Apr 26, 2026

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

19.6K
Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

14.8K
Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles
10:38

Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles

Published on: September 21, 2018

11.7K

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Centrosomes, organized by centrioles, are crucial microtubule-organizing centers in animal cells.
  • Centrioles are vital for cell division, polarization, and forming cilia/flagella.
  • Errors in centriole number or function are linked to diseases like cancer and ciliopathies.

Purpose of the Study:

  • To review recent advances in understanding centriole assembly and duplication control.
  • To present a general model for centriole duplication initiation and cell cycle licensing.
  • To discuss variations in centriole multiplication, such as deuterosomes and blepharoplasts.

Main Methods:

  • Review of current literature on centriole biogenesis and duplication.
  • Analysis of models for centriole duplication control mechanisms.
  • Focus on specialized structures involved in multiple centriole formation.

Main Results:

  • A proposed model where cooperative binding of factors defines the origin of duplication.
  • Mitotic passage licenses centrioles for subsequent duplication rounds.
  • Identification of deuterosomes and blepharoplasts as key structures in amplified centriole production.

Conclusions:

  • Centriole duplication is a complex process with conserved and variable mechanisms.
  • Understanding centriole duplication is crucial for addressing associated human diseases.
  • Further research into these mechanisms can reveal new therapeutic targets.