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Updated: Apr 26, 2026

Author Spotlight: Investigating Asymmetric Cell Division Dynamics: A Protocol for Live-Imaging of Drosophila Larval Brain Explants
Published on: June 23, 2023
When fate follows age: unequal centrosomes in asymmetric cell division
Jose Reina1, Cayetano Gonzalez2
1Institute for Research in Biomedicine (IRB-Barcelona), Baldiri Reixac 10, Barcelona 08028, Spain.
Abstract:
A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncertain. Here, we present the different cell types in which correlated centrosome age and fate has been documented, review current knowledge on the underlying molecular mechanisms and discuss possible functional implications of this process.
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