Highly selective fluorescence off-on probes for biothiols and imaging in live cells
Di Zhang1, Wei Chen, Jianming Kang
1College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China. yeyong03@tsinghua.org.cn.
Organic & Biomolecular Chemistry
|July 23, 2014
Abstract:
Three sulfonyl benzothiazole-based fluorescent probes (, , and ) for the detection of biothiols (cysteine, homocysteine, and glutathione) are developed based on thiol-mediated nucleophilic aromatic substitutions. The probes exhibited good selectivity and sensitivity toward biothiols over other analytes. The probes were successfully applied for visualizing endogenous thiols in living cells.
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