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Updated: Apr 26, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
Lucie Aliouane1, Sovy Chao2, Leyre Brizuela3
1Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507 & FR3038, ENSICAEN, Normandie Université, Université de Caen Basse-Normandie, 6 Bd du Maréchal Juin, Caen 14050, France; Normandie Université, COBRA, UMR 6014 & FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
Abstract:
The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), mediates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.
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