Photodynamic assisted surgical resection and treatment of malignant brain tumours technique, technology and clinical
1Department of Neurosurgery, South Block, Level 6, Ninewells hospital and Medical School, Dundee DD1 9SY, UK.
Abstract:
Malignant brain tumours have a dismal prognosis with current state of the art technology. The main reasons for this lost battle in the battlefield of cancer are tumour cell invisibility to the surgical microscope and brain invasion. However, the vast majority of these tumours relapse locally making local radical removal the main strategy in their successful eradication. PDD and PDT combined with new technology stands a very good chance of achieving this goal by maximising tumour resection (PDD) and selective tumour kill (PDT). The aim of this paper is to explain how this is done at Ninewells Hospital and Medical School, Dundee, Scotland. The technique and technology described in this paper, provide a means of diffusing the light to the periphery of the tumour cavity with subsequent therapeutic sessions and treatment dose escalation at the bedside, saving time and resources.
Insights
New techniques combining photodynamic diagnosis (PDD) and photodynamic therapy (PDT) improve malignant brain tumor resection and destruction. This approach enhances tumor visibility for maximal surgical removal and targeted cell kill, offering a promising strategy for improved patient outcomes.
Area of Science:
- Oncology
- Neurosurgery
- Biomedical Engineering
Background:
- Malignant brain tumors have a poor prognosis due to challenges in surgical visualization and tumor cell invasion.
- Local recurrence is common, emphasizing the need for effective local eradication strategies.
Purpose of the Study:
- To describe a novel technique combining photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for improved malignant brain tumor treatment.
- To detail the application of this technology at Ninewells Hospital and Medical School, Dundee, Scotland.
Main Methods:
- Utilizing PDD to enhance tumor visualization during surgery, maximizing tumor resection.
- Employing PDT for selective tumor cell destruction in the post-resection cavity.
- Implementing a technology for diffused light delivery to the tumor periphery for targeted therapy.
Main Results:
- The described technique aims to maximize tumor resection through enhanced visualization (PDD).
- Selective tumor cell kill is achieved via PDT, addressing residual microscopic disease.
- The technology allows for bedside treatment escalation, optimizing resource utilization.
Conclusions:
- The combination of PDD and PDT offers a promising strategy for improving local control of malignant brain tumors.
- This integrated approach enhances both surgical resection and targeted tumor eradication.
- The described technique has the potential to improve patient prognosis by addressing key challenges in brain tumor treatment.
