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Updated: Apr 26, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
Published on: February 28, 2019
Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design
Joo Chuan Tong1, Tin Wee Tan, Shoba Ranganathan
1Institute of High Performance Computing, 1 Fusionopolis Way, #16-16, Connexis North Tower, Singapore, 138632, Singapore, victor@bic.nus.edu.sg.
Abstract:
Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics.
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