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HLA typing intestinohepatic schistosomiasis
Patients with intestinal bilharziasis, particularly those with hepatosplenomegaly and polyposis, show a higher frequency of the HLA-B8 antigen. This finding suggests a potential genetic link in disease presentation.
Area of Science:
- Immunogenetics
- Tropical Medicine
- Gastroenterology
Background:
- Intestinal bilharziasis is a significant parasitic disease.
- Hepatosplenomegaly and intestinal polyposis are known complications.
- The role of human leukocyte antigens (HLA) in disease susceptibility is under investigation.
Purpose of the Study:
- To investigate the association between specific HLA antigens and intestinal bilharziasis.
- To determine if HLA antigen frequencies differ in patients with complications like hepatosplenomegaly and polyposis.
Main Methods:
- Patients with intestinal bilharziasis (simple/complicated) and healthy controls were recruited.
- Diagnostic methods included complete blood count, urine/stool analysis, liver function tests, liver/rectal biopsies, and sigmoidoscopy.
- Human leukocyte antigen (HLA) typing was performed using the microcytotoxicity test.
Main Results:
- A statistically significant increase in HLA-B8 antigen frequency was observed in patients with intestinal bilharziasis, especially those with hepatosplenomegaly and polyposis, compared to controls (P < 0.01).
- HLA-B8 was also significantly more frequent in patients with hepatosplenomegaly (P < 0.05).
- HLA-A25 and HLA-A26 showed increased frequencies across all patient groups (P < 0.05).
Conclusions:
- Patients with bilharzial hepatosplenomegaly, particularly with intestinal polyposis, exhibit a high frequency of the HLA-B8 antigen.
- These findings suggest a genetic predisposition associated with specific HLA types in the development of severe intestinal bilharziasis complications.
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