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Updated: Apr 26, 2026

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
Published on: July 20, 2022
Enhanced production techniques, properties and uses of coenzyme Q10
Jean de Dieu Ndikubwimana1, Byong H Lee
1School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Abstract:
Coenzyme Q10 (CoQ10) is an essential component of the respiratory chain which produces ATP. It is formed from the conjugation of a benzoquinone ring with a hydrophobic isoprenoid chain. Efforts on the production of CoQ10 by microorganisms focus on the development of potent strains by conventional mutagenesis and metabolic engineering especially in Escherichia coli, analysis and modification of the key metabolic pathways and optimization of fermentation strategies. CoQ10 has excellent antioxidant properties and is beneficial in the treatment of several human diseases. The present review covers the current strategies used to improve and/or engineer CoQ10 production in microbes, the yields obtained in light of the current knowledge on the biosynthesis of this molecule. It also highlights the medical effects of CoQ10.
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