Current state of mTOR targeting in human breast cancer

Area of Science:

• Molecular Biology
• Oncology
• Cellular Signaling

Background:

• The mechanistic target of rapamycin (mTOR) pathway is implicated in human oncogenesis.
• Research into mTOR's role in cancer development is highly active.
• This review focuses on mTOR's function in human carcinogenesis, with a special emphasis on breast cancer.

Purpose of the Study:

• To review the current understanding of the mTOR pathway, including its components and interactions.
• To elucidate the role of mTOR in human carcinogenesis.
• To discuss the therapeutic targeting of mTOR in human breast cancer.

Main Methods:

• Outline the components of the two mTOR complexes.
• Define the distinct roles and interactions of mTOR complexes.
• Review current therapeutic strategies targeting mTOR in breast cancer.

Main Results:

• Understanding of the mTOR pathway's organization and interactions is continually advancing.
• Progress in therapeutically targeting the mTOR pathway in human breast cancer has been incremental.
• The review synthesizes existing literature on mTOR in breast cancer.

Conclusions:

• A deeper comprehension of the mTOR pathway's role in breast cancer is essential for future progress.
• This mini-review provides valuable insights into the current literature on mTOR and breast cancer.
• Further research is needed to fully leverage mTOR-targeted therapies.