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Hemolytic crisis in a G6PD-deficient infant after ingestion of pumpkin

Gian Vincenzo Zuccotti, Francesca Redaelli, Valentina Gualdi

  • 1Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Via G,B, Grassi, 74, 20157 Milan, Italy. valentina.fabiano@unimi.it.

Italian Journal of Pediatrics
|July 23, 2014
PubMed

Insights

A baby with Glucose-6-Phosphate Dehydrogenase deficiency experienced severe jaundice and anemia. This was caused by cross-contaminated food, marking the first reported case of hemolysis from indirectly ingested fava beans.

Area of Science:

  • Pediatrics
  • Toxicology
  • Genetics

Background:

  • Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is a common genetic disorder.
  • Hemolytic anemia can be triggered by certain foods, infections, or drugs in individuals with G6PD deficiency.
  • Fava beans are a well-known trigger for hemolysis in G6PD deficient individuals.

Observation:

  • An 8-month-old infant with diagnosed G6PD deficiency presented with acute severe jaundice and anemia.
  • The infant had no history of drug use or direct fava bean consumption.
  • Fava bean DNA was detected on pumpkin consumed by the infant prior to symptom onset.

Findings:

  • This case represents the first documented instance of hemolysis triggered by the ingestion of food cross-contaminated with fava beans.
  • The presence of fava bean DNA on the pumpkin confirmed the source of the trigger.
  • The infant required blood transfusion due to the severity of the anemia.

Implications:

  • Highlights the risk of cross-contamination in food preparation for vulnerable populations.
  • Emphasizes the need for heightened awareness regarding potential hidden sources of G6PD triggers.
  • Suggests improved food safety protocols to prevent accidental ingestion of allergens or toxins.

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