Related Experiment Video

Updated: Apr 26, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

560

[LDL cholesterol control in patients with very high cardiovascular risk. A simplified algorithm for achieving LDL

Carlos Guijarro-Herraiz1, Luis Masana-Marin2, Enrique Galve3

  • 1Servicio de Medicina Interna, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Alcorcón, Madrid, España; Grupo de Trabajo de la Sociedad Española de Arteriosclerosis..

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|July 23, 2014
PubMed

Insights

Achieving low-density lipoprotein-cholesterol (LDL-c) goals is critical for very high cardiovascular risk patients, but often unmet. This study explores the problem

Area of Science:

  • Cardiology
  • Lipid Metabolism
  • Preventive Medicine

Context:

  • Cardiovascular disease prevention guidelines in Spain and Europe recommend LDL-c below 70 mg/dL for very high-risk patients.
  • Current achievement rates for LDL-c targets in this high-risk population are notably low.
  • Understanding the prevalence and underlying causes of treatment goal non-attainment is crucial.

Purpose:

  • To describe the prevalence and reasons for suboptimal LDL-c reduction in very high cardiovascular risk patients.
  • To provide recommendations and tools for optimizing lipid-lowering treatment strategies.
  • To introduce a novel, simple two-step algorithm designed to help patients achieve LDL-c goals efficiently.

Summary:

  • This article addresses the challenge of achieving target low-density lipoprotein-cholesterol (LDL-c) levels (<70 mg/dL) in very high cardiovascular risk individuals, a goal frequently unmet.
  • It details the prevalence of this issue, explores contributing factors, and offers evidence-based recommendations and practical tools for effective treatment planning.
  • A new, simplified two-step algorithm is presented to facilitate goal attainment with minimal clinical encounters.

Impact:

  • Aims to improve clinical outcomes by enhancing the achievement of LDL-c targets in high-risk cardiovascular patients.
  • Provides healthcare professionals with actionable strategies and a novel tool to manage hyperlipidemia more effectively.
  • Contributes to reducing the burden of cardiovascular events through better lipid management in vulnerable populations.

Keywords:
AlgorithmAlgoritmoColesterol LDLFactores de riesgoHipercolesterolemiaHipolipemiantesHypercholesterolemiaHypolipidemic agentsLDL cholesterolRisk factors

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

8.4K
Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

800

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
719
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
888
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
839
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.4K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.0K