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Related Experiment Videos

Dopa in plasma increases during acute exercise and after exercise training.

M L Devalon1, T D Miller, R W Squires

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

The Journal of Laboratory and Clinical Medicine
|September 1, 1989
PubMed
Summary

Exercise training significantly increases resting plasma dihydroxyphenylalanine (dopa) levels in older men, correlating with improved cardiorespiratory fitness. This suggests enhanced catecholamine synthesis capacity with regular physical activity.

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Area of Science:

  • Exercise Physiology
  • Neuroendocrinology
  • Aging Research

Background:

  • Plasma dihydroxyphenylalanine (dopa) originates in sympathetic neurons and may reflect tyrosine hydroxylase activity.
  • Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis.
  • The impact of exercise and training on dopa and catecholamine levels in older adults is not well understood.

Purpose of the Study:

  • To investigate the effects of acute exercise and chronic exercise training on plasma dopa and catecholamine levels.
  • To examine these effects in healthy, older men.

Main Methods:

  • Blood samples were collected from 19 older men (52-75 years) at rest, during submaximal exercise, peak exercise, and post-exercise.
  • Measurements included plasma dopa, dopamine, epinephrine, and norepinephrine using high-performance liquid chromatography.

Related Experiment Videos

  • Ten participants completed 12-16 weeks of supervised exercise training; controls maintained normal activity.

    • Main Results:

    • Resting dopa levels were higher than free dopamine, epinephrine, and norepinephrine.
    • Acute exercise increased dopa and catecholamine levels, with dopa showing a substantial rise.
    • Exercise training significantly increased basal dopa levels, which correlated with improved peak oxygen uptake; trained individuals showed increased peak exercise catecholamines.

    Conclusions:

    • Exercise training enhances basal plasma dopa levels in older men, indicating increased catecholamine synthesis potential.
    • The observed increase in dopa correlates with improved cardiorespiratory fitness (peak oxygen uptake).
    • Exercise training also augments catecholamine responses during peak exercise in this population.