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Updated: Apr 26, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Adjuvant therapy for renal cell carcinoma

Alvaro Pinto1

  • 1Medical Oncology Department, University Hospital La Paz - IdiPAZ, Madrid, Spain.

Clinical Genitourinary Cancer
|July 23, 2014
PubMed

Insights

Adjuvant therapies for advanced kidney cancer show limited benefit, despite advancements in targeted treatments. Ongoing clinical trials are investigating new options for patients at high risk of relapse.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Recent U.S. Food and Drug Administration approvals of targeted therapies have improved outcomes for advanced renal cell carcinoma.
  • Despite progress in advanced disease, adjuvant therapies have not consistently shown clear benefits in preventing kidney cancer recurrence.

Purpose of the Study:

  • To review current data on adjuvant therapy for kidney cancer.
  • To summarize ongoing clinical trials for high-risk kidney cancer patients.

Main Methods:

  • Review of available data on adjuvant treatments for renal cell carcinoma.
  • Analysis of ongoing clinical trials in the adjuvant setting.

Main Results:

  • Targeted therapies have improved progression-free survival and quality of life in advanced renal cell carcinoma.
  • Adjuvant immune, hormonal, or targeted therapies have not yet demonstrated a clear benefit in preventing relapse.

Conclusions:

  • The role of adjuvant therapy in kidney cancer remains an area of active investigation.
  • Clinical trials are crucial for evaluating new adjuvant treatment strategies for patients at high risk of recurrence.
Keywords:
Clinical trialsImmune therapyRelapse riskRisk reductionTargeted therapy

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