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Lipophilic cationic porphyrins as photodynamic sensitisers-Synthesis and structure-activity relationships
Robert Hudson1, Huguette Savoie, Ross W Boyle
1Department of Chemistry, University of Hull, Kingston-upon-Hull, East Yorkshire HU6 7RX, UK.
Photodiagnosis and Photodynamic Therapy
|July 23, 2014
Abstract:
A convenient synthesis of a range of phosphorous and nitrogen centred lipophilic cationic porphyrins is described. In vitro assays for photodynamic activity against human colorectal adenocarcinoma cells (HT-29) reveal significant differences based on substituents around the cation centres.
