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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Trial Watch: Adoptive cell transfer for anticancer immunotherapy.

Fernando Aranda1, Erika Vacchelli1, Florine Obrist1

  • 1Gustave Roussy; Villejuif, France ; INSERM, UMRS1138; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France ; Université Paris-Sud/Paris XI; Paris, France.

Oncoimmunology
|July 23, 2014
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Summary

Adoptive cell transfer (ACT) is an evolving cancer immunotherapy where patient cells are modified and reintroduced to fight tumors. Recent advancements focus on enhancing ACT

Keywords:
CD19chimeric antigen receptorcytokine-induced killer cellsinterleukin-2peripheral blood lymphocytes

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Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Adoptive cell transfer (ACT) is a cornerstone of modern cancer immunotherapy.
  • This technique involves isolating, modifying, and reinfusing a patient's own immune cells to combat cancer.
  • Significant progress has been made in refining ACT protocols for improved efficacy and safety.

Approach:

  • This review summarizes recent high-impact studies and newly launched clinical trials in ACT for oncological indications.
  • It covers advancements in ex vivo cell manipulation, including genetic engineering for targeted antigen recognition and enhanced persistence.
  • The focus is on evaluating the safety and therapeutic potential of novel ACT strategies.

Key Points:

  • ACT protocols are becoming increasingly efficient and safer.
  • Genetic manipulation of cells enhances targeting of tumor-associated antigens and improves in vivo persistence.
  • The number of clinical trials investigating ACT for various cancers is rapidly expanding.

Conclusions:

  • Recent developments indicate a promising future for ACT in cancer treatment.
  • Ongoing research and clinical trials are crucial for realizing the full potential of ACT.
  • Continued innovation in ACT aims to provide more effective and personalized cancer immunotherapies.