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Immune response markers in sentinel nodes may predict melanoma progression
Monica Rodolfo1, Chiara Castelli1, Licia Rivoltini1
1Unit of Immunotherapy; Fondazione IRCCS Istituto Nazionale Tumori; Milan, Italy.
Oncoimmunology
|July 23, 2014
Abstract:
We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.
