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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Related Experiment Video

Updated: Apr 26, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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T cell immunosurveillance controls B lymphoma development.

Axel Kallies1

  • 1The Walter and Eliza Hall Institute of Medical Research; Parkville, VIC Australia.

Oncoimmunology
|July 23, 2014
PubMed
Summary

T cells are critical for immunosurveillance of B cell lymphomas. CD8+ T cells eliminate mutated B cells that resist programmed cell death, preventing lymphoma development.

Area of Science:

  • Immunology
  • Cancer Biology
  • Hematology

Background:

  • B cell lymphomas arise from mutations affecting plasma cell differentiation.
  • Immune surveillance plays a role in controlling nascent lymphomas.

Purpose of the Study:

  • To elucidate the role of T cells in immunosurveillance of B cell lymphomas.
  • To identify mechanisms by which T cells prevent lymphoma development.

Main Methods:

  • Investigated the interaction between T cells and mutated B cells.
  • Analyzed the expression of co-stimulatory molecules and Fas death receptor on B cells.

Main Results:

  • CD8+ T cells were found to be critical for immunosurveillance.
  • Mutated B cells that failed to downregulate co-stimulatory machinery and Fas were eliminated.
Keywords:
AIDBcl6CD8+ T cellsgerminal centerimmune surveillancemutations

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  • This elimination process constrains B lymphoma pathogenesis.

    • Conclusions:

    • T cell immunosurveillance is essential for preventing B cell lymphoma.
    • Targeting T cell responses may offer therapeutic strategies for B cell lymphomas.