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Neuro-pharmacological effects of Crinum zeylanicum in mice
Adeniyi Yahaya Tijani1, Oluwakanyinsola Adeola Salawu1, Good-Luck Jaiyeoba1
1Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria.
Objectives:
The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system.
Materials And Methods:
C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance.
Results:
The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod.
Conclusion:
The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
