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Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes
F Majone1, L Busulini, A Capozzi
1Department of Biology, University of Padua, Italy.
Mutation Research
|September 1, 1989
Abstract:
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions an increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.