Related Experiment Video
Updated: Aug 17, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Four-muscle tenotomy surgery for nystagmus
Margaret A Greven1, Leonard B Nelson
1Department of Pediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.
Purpose Of Review:
To describe the history and literature related to four-muscle tenotomy procedure for nystagmus.
Recent Findings:
The concept of four-muscle tenotomy surgery for nystagmus initially arose from objective eye movement recordings of patients with nystagmus and an eccentric face turn who had undergone the Anderson-Kestenbaum procedure. These eye movement recordings demonstrated secondary benefits, including broadening of the null region, improved visual acuity, and improved nystagmus waveforms. Studies initially performed in dogs validated the theory that such positive effects could be obtained by horizontal four-muscle tenotomy and reattachment without transposition. Subsequent studies in humans have demonstrated that the procedure results in improved visual acuity, broadening of the null zone, and improved target acquisition in patients with nystagmus. New theories have been described regarding techniques to augment the effects of the procedure and/or replicate its effects with a safer, less invasive alternative.
Summary:
Horizontal four-muscle tenotomy has proven to be an effective procedure for reducing nystagmus, broadening the null position, and improving visual acuity in primary position for patients with nystagmus.
More Related Videos
Related Concept Videos
Skeletal Muscle Relaxants: Therapeutic Uses
Muscles of the Eye
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...

