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Updated: Apr 26, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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[Harmless bruises? Coagulopathy despite normal INR]

Ladina Greuter1, Manuela Schöb1, Thomas Lehmann2

  • 1Departement für Innere Medizin, Klinik für Allgemeine Innere Medizin/Hausarztmedizin, Kantonsspital St. Gallen.

Praxis
|July 24, 2014
PubMed

Acquired hemophilia is a rare but severe bleeding disorder caused by autoantibodies mostly against factor VIII. Clinically it mostly presents with soft tissue and muscular bleeding. Diagnostics include a prolonged aPTT, antibodies against FVIII and a reduced FVIII titre. Acute bleeding is controlled with recombinant factor VIIa (NovoSeven(®)) or activated prothrombin complex (FEIBA(®)), as both bypass FVIII in the coagulation pathway. Treatment to reduce the inhibitor consists of immunosuppression with corticosteroids, cyclophosphamid and can be extended with rituximab.

Keywords:
HemmkörperhämophilieImmunsuppressionacquired haemophiliaactivated prothrombin complexaktivierter Prothrombinkompleximmunosuppressionisolated prolonged aPTTisoliert verlängerte aPTTrecombinant factor VIIarekombinanter Faktor VIIa

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