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Updated: Apr 26, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Fungal polyketide biosynthesis - a personal perspective
1School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. tom.simpson@bristol.ac.uk.
Abstract:
This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural characterisation of PKS domains, fungal genome sequencing, through to genetic engineering of whole pathways. This article forms part of a "trilogy" of related Viewpoints from three close contemporaries who have been privileged to share in these developments since their outset over forty years ago and to enjoy both professional and personal interactions throughout that time.
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