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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Notch Signaling Pathway03:14

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Signal Transduction: Overview01:26

Signal Transduction: Overview

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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Related Experiment Video

Updated: Apr 26, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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Introduction to Notch signaling.

Shinya Yamamoto1, Karen L Schulze, Hugo J Bellen

  • 1Department of Molecular and Human Genetics, Program in Developmental Biology, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA, yamamoto@bcm.edu.

Methods in Molecular Biology (Clifton, N.J.)
|July 24, 2014
PubMed
Summary

Notch signaling, a vital intercellular communication pathway, is conserved across species and implicated in various diseases, including cancer. Research is exploring its components as potential therapeutic drug targets.

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Area of Science:

  • Cellular Biology
  • Genetics
  • Developmental Biology

Background:

  • Notch signaling is a fundamental intercellular communication pathway conserved across diverse organisms.
  • Its discovery dates back to early genetic studies in Drosophila melanogaster.
  • Decades of research have elucidated its molecular mechanisms and biological roles.

Purpose of the Study:

  • To provide a historical overview of Notch signaling research.
  • To discuss the core principles and unique features of the Notch pathway.
  • To highlight its involvement in diseases and potential as a therapeutic target.

Main Methods:

  • Molecular cloning of Notch pathway components.
  • Genetic, cell biological, biochemical, and structural analyses.
  • Bioinformatic, genetic screens, and systems approaches.

Main Results:

  • Established the evolutionary conservation and basic molecular logic of Notch signaling.
  • Identified numerous interacting genes that fine-tune the pathway.
  • Linked Notch signaling to congenital disorders, stroke, and cancer.

Conclusions:

  • Notch signaling is a crucial pathway with significant implications for human health and disease.
  • Key components are being investigated as drug targets for therapeutic interventions.
  • Integrated approaches are essential for further understanding and manipulating Notch signaling in vivo and clinically.