Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.9K
4.9K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

1.8K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K
Modeling of Diode Forward Characteristics01:19

Modeling of Diode Forward Characteristics

1.4K
Understanding the behavior of diodes when forward-biased is a fundamental aspect of electronic circuit design and analysis. This analysis primarily utilizes two models: the exponential diode model and the constant-voltage-drop model. The exponential model comes into play when the source voltage exceeds 0.5 volts, pushing the diode current to rise exponentially above the saturation current. This relationship is graphically depicted in the current-voltage (I-V) curve, illustrating the diode's...
1.4K
Modeling of Diode Reverse Characteristics01:14

Modeling of Diode Reverse Characteristics

888
In electronic circuits, reverse-biased diode configurations are critical for regulating voltage levels. Zener diodes exploit the reverse breakdown phenomenon and exhibit a controlled breakdown at a specific Zener voltage (VZ). They are designed to maintain a constant voltage across their terminals and are commonly used for voltage regulation in circuits.
When a reverse voltage applied to a Zener diode exceeds its breakdown voltage, the diode enters the breakdown region. At this point, the...
888
Modeling with Differential Equations01:25

Modeling with Differential Equations

328
Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...
328

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition.

Science advances·2026
Same author

Modeling of gene regulatory networks: an annotated glossary.

Trends in plant science·2026
Same author

A model of transcriptional bursting dynamics based on coupling between chromatin and enhancer states.

bioRxiv : the preprint server for biology·2025
Same author

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.

Cell·2025
Same author

Spatial ploidy inference using quantitative imaging.

Cell reports methods·2025
Same author

A common pathway controls cell size in the sepal and leaf epidermis leading to a nonrandom pattern of giant cells.

PLoS biology·2025

Related Experiment Video

Updated: Apr 26, 2026

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

2.1K

Modeling Notch signaling: a practical tutorial.

Pau Formosa-Jordan1, David Sprinzak

  • 1Department of Structure and Constituents of Matter, Physics, University of Barcelona, Martí i Franquès 1, Barcelona, 08028, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|July 24, 2014
PubMed
Summary
This summary is machine-generated.

This tutorial introduces computational modeling for Notch signaling and lateral inhibition patterning. A provided MATLAB code enables simulations and exploration of Notch pathway dynamics.

More Related Videos

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

3.4K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

7.7K

Related Experiment Videos

Last Updated: Apr 26, 2026

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

2.1K
A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

3.4K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

7.7K

Area of Science:

  • Computational biology
  • Systems biology
  • Developmental biology

Background:

  • Theoretical and computational approaches are increasingly used to understand complex biological processes like Notch signaling.
  • In silico methodologies offer dynamic insights into Notch-dependent patterning that may not be intuitive through experimental observation alone.

Purpose of the Study:

  • To provide an introductory tutorial on exploring mathematical models of Notch-mediated processes.
  • To guide users with basic computational knowledge in performing numerical simulations of these models.
  • To demonstrate the definition and simulation of lateral inhibition patterning models.

Main Methods:

  • Explanation of how to define and simulate models of lateral inhibition patterning.
  • Provision of a user-friendly MATLAB code for simulating various lateral inhibition models.
  • Guidance on presenting results from computational models.

Main Results:

  • The chapter facilitates the exploration of Notch signaling and lateral inhibition patterning through computational modeling.
  • A practical MATLAB code is offered for simulating and visualizing these biological processes.
  • Users can gain dynamic insights into Notch-dependent patterning.

Conclusions:

  • This tutorial serves as a starting point for investigating Notch pathway regulation and dynamics.
  • The provided computational tools can be adapted for more specific and complex models.
  • In silico approaches are valuable for elucidating intricate biological patterning mechanisms.