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Related Experiment Video

Updated: Apr 26, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Airways resistance in bronchial challenge testing.

Mark A Baxter¹, Dawn Coates, Andrew M Wilson

¹Norfolk and Norwich University Hospital, Respiratory Medicine , Colney Lane, Norwich, Norfolk , UK.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma

|July 24, 2014

Summary

The interrupter technique (RInt) for measuring airway resistance showed good agreement with spirometry (FEV1) during histamine challenge tests. RInt was also better tolerated by patients, suggesting it is a viable alternative for assessing airflow obstruction.

Keywords:

Diagnostics management/control physiology treatment

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Area of Science:

Pulmonary Medicine
Respiratory Physiology

Background:

Airflow obstruction assessment can be performed using spirometry or by measuring airways resistance.
The interrupter technique (RInt) offers a handheld method for measuring airways resistance.
Comparing RInt to spirometry (FEV1) during histamine challenge tests is crucial for understanding its clinical utility.

Purpose of the Study:

To compare the interrupter technique (RInt) with forced expiratory volume in 1 second (FEV1) during histamine challenge tests.
To evaluate the agreement between RInt and FEV1 in identifying airflow obstruction.
To assess patient tolerance of RInt compared to spirometry.

Main Methods:

Twenty-nine patients underwent histamine challenge tests, with measurements of RInt and FEV1.
Dose-response curves were generated to determine provocation concentrations (PC) for both RInt and FEV1.
Patient-reported symptoms (breathlessness, dizziness, tiredness) were recorded using visual analogue scales.

Main Results:

A RInt provocation concentration (PC20) demonstrated the best agreement with FEV1 PC20 (Kappa 0.39, p=0.024).
A significant negative correlation (r=-0.94) was observed between RInt and FEV1.
Patients reported significantly less breathlessness with RInt compared to spirometry.

Conclusions:

The interrupter technique (RInt) is a well-tolerated alternative to spirometry for assessing airway resistance.
A doubling of airway resistance measured by RInt shows good agreement with FEV1 PC20.
RInt offers a promising method for evaluating airflow obstruction in clinical settings.