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Updated: Apr 26, 2026

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Published on: October 17, 2025
Objective:
To perform a review of Tuberous sclerosis complex and its complications during the pregnancy from up to date scientific literature.
Design:
Complex systematic review of the literature.
Setting:
2nd Department of Obstetrics and Gynaecology, University Hospital Bratislava, Comenius University, Bratislava, Slovak Republic.
Methods:
Complex analysis of the syndrome, systematic search of MEDLINE and Slovak Medical Library. The reason to create a complex review of this syndrome was our clinical experience with one of the most acute lifethreatening condition of this syndrome - acute retroperitoneal haemorrhage in the pregnancy.
Conclusion:
Tuberous sclerosis can cause a rare, but potentially lifethreatening complications, especially during the pregnancy. These should be carefully dispesarized and in complicated cases acute radical management should be considered.
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