Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Larynx01:21

Larynx

6.3K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
6.3K
Esophageal Achalasia01:27

Esophageal Achalasia

37
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
37
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

24
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
24
Respiratory System Abnormal Finding II: Palpation and Auscultation01:31

Respiratory System Abnormal Finding II: Palpation and Auscultation

2.1K
In assessing respiratory abnormalities, palpation and auscultation are critical tools for detecting and interpreting various pathophysiological changes. These techniques provide insight into underlying disorders by evaluating tactile sensations and sounds produced by the respiratory system.
Palpation Findings
During a respiratory assessment, palpation can reveal several vital abnormalities:
2.1K
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serological progression and time to seroconversion in serodiscordant and seronegative dogs tested for visceral leishmaniasis in an endemic area of Brazil.

Acta tropica·2026
Same author

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000-2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis.

Zoonoses and public health·2026
Same author

Adequacy of nutritional status and dietary intake of adult and elderly patients with American Tegumentary Leishmaniasis.

Einstein (Sao Paulo, Brazil)·2025
Same author

Comparison of the spatial and temporal distribution of cutaneous and mucosal leishmaniasis in the state of Rio de Janeiro between 2001 and 2011.

PloS one·2024
Same author

Self-reporting of hearing loss and tinnitus in the diagnosis of ototoxicity by meglumine antimoniate in patients treated for American tegumentary Leishmaniasis.

PloS one·2024
Same author

Development of a mobile app for the evaluation of patients with chronic rhinosinusitis.

Brazilian journal of otorhinolaryngology·2024

Related Experiment Video

Updated: Apr 26, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

21.2K

Voice disorders in mucosal leishmaniasis.

Ana Cristina Nunes Ruas1, Márcia Mendonça Lucena2, Ananda Dutra da Costa2

  • 1Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro-RJ, Brazil; Department of Speech Pathology, Federal University of Rio de Janeiro, Rio de Janeiro-RJ, Brazil.

Plos One
|July 24, 2014
PubMed
Summary

Mucosal leishmaniasis (ML) frequently causes voice problems, even without direct laryngeal lesions. These voice quality changes are likely due to affected resonance structures or compensatory mechanisms in ML patients.

More Related Videos

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase
05:55

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

880
In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

7.7K

Related Experiment Videos

Last Updated: Apr 26, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

21.2K
In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase
05:55

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

880
In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

7.7K

Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Speech-Language Pathology

Background:

  • Leishmaniasis is a major global infectious disease causing deformities.
  • Mucosal leishmaniasis (ML) often follows cutaneous leishmaniasis and can cause lasting damage.
  • Untreated ML sequelae impact swallowing, breathing, voice, and speech, necessitating rehabilitation.

Purpose of the Study:

  • To characterize the anatomical locations of lesions in mucosal leishmaniasis patients.
  • To assess the voice quality of individuals with mucosal leishmaniasis.

Main Methods:

  • A descriptive transversal study of 26 ML patients treated between 2010-2013.
  • Otorhinolaryngologic examination via endoscopy of upper airways and digestive tract.
  • Speech-language assessment including anamnesis, auditory perception, phonation times, and acoustic analysis.

Main Results:

  • Lesions were most common in nasal (88.5%), oral (38.5%), pharyngeal (34.6%), and laryngeal (19.2%) structures.
  • Nasal obstruction (73.1%) was the primary complaint, followed by dysphonia (38.5%), odynophagia (30.8%), and dysphagia (26.9%).
  • Voice quality perturbations were observed in 84.6% of patients, significantly associated with laryngeal, pharyngeal, and oral lesions.

Conclusions:

  • Vocal quality perturbations are common in ML patients, irrespective of laryngeal involvement.
  • These voice changes may stem from resonance structure disorders (larynx, pharynx, nasal/oral cavities).
  • Compensatory mechanisms due to upper airway/digestive tract lesions likely contribute to voice alterations.