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Updated: Apr 26, 2026
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Optimization of reconstruction parameters using a multi-focus fan beam collimator in myocardial perfusion single
Shuji Kenda1, Hideo Onishi, Kenta Nakamoto
1Program in Health and Welfare, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima.
Purpose:
The aim of this study was to optimize the reconstruction parameters for ordered subset conjugate gradient minimization (OSCGM) reconstruction using a multifocus fan beam collimator in myocardial perfusion single photon emission computed tomography (SPECT).
Method:
We attempted to validate the following performance of OSCGM reconstruction parameters (iteration and subset). SPECT images were acquired using a dual-head gamma camera with IQ mode acquisition systems from a RH-2 cardiac phantom containing a 99m-Tc solution. The performance was evaluated using reconstruction parameters (product of subset and iteration: SI) with image contrast, LV volume [using quantitative perfusion SPECT (QPS)], root mean square uncertainty (RMSU), and normalized mean squared error (NMSE).
Results:
The best results (contrast, uniformity, LV volume, and NMSE) were found for SI: 30. LV volume indicated the true volume for subset: 1 and iteration: 30, and LV volume was underestimated by 10% for iteration >20, and subset >1.
Conclusion:
The results of this myocardial perfusion SPECT study suggest the optimal OSCGM reconstruction parameter to be subset: 1 and iteration: 30 using a multifocus fan beam collimator.
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