Consensus recommendations for using the Multiplate(®) for platelet function monitoring before cardiac surgery

Area of Science:

• Cardiology
• Hematology
• Anesthesiology

Background:

• Patients undergoing urgent cardiac surgery often take antiplatelet drugs, increasing bleeding risk.
• Balancing thrombotic risk and surgical bleeding is a clinical challenge.
• Preoperative platelet function monitoring is crucial for managing antiplatelet therapy.

Purpose of the Study:

• To provide recommendations for using platelet function monitoring in cardiac surgery patients.
• To guide the perioperative management of antiplatelet therapy.
• To optimize patient outcomes by minimizing bleeding and thrombotic complications.

Main Methods:

• Utilizing the Multiplate® (multiple electrode impedance platelet aggregometer) for point-of-care platelet function testing.
• Analyzing real-world, collective clinical experience with the device.
• Developing recommendations for predicting platelet transfusion needs and determining post-cessation waiting periods for P2Y12 inhibitors.

Main Results:

• The Multiplate® analyser can effectively monitor platelet function in patients on antiplatelet therapy.
• Recommendations are provided for individualized perioperative management strategies.
• Evidence-based guidance for predicting transfusion requirements and optimizing waiting times after P2Y12 inhibitor cessation.

Conclusions:

• Platelet function monitoring is essential for safe and effective perioperative management in cardiac surgery.
• The Multiplate® analyser offers a valuable tool for personalized antiplatelet therapy management.
• Recommendations support improved clinical decision-making regarding platelet transfusions and drug cessation timing.