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Stability studies on piroxicam encapsulated niosomes
Zehra Ceren Ertekin, Zerrin Sezgin Bayindir, Nilufer Yuksel1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey. nyuksel@pharmacy.ankara.edu.tr.
Current Drug Delivery
|July 25, 2014
Summary
Niosomes loaded with piroxicam showed sustained drug release, with minimal leakage (1.56-6.63%) over three months. Lyophilized niosomes stored at 5°C demonstrated optimal stability, though further optimization is recommended.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Niosomes offer advantages as drug delivery systems but face stability challenges.
- Investigating niosome stability is crucial for their clinical application.
- Piroxicam was selected as a model drug to assess niosome performance.
Purpose of the Study:
- To evaluate the stability of piroxicam-loaded niosomes under various storage conditions.
- To compare the stability of different niosome formulations (aqueous, lyophilized, lyophilized with cryoprotectant).
- To assess the impact of storage on niosome characteristics and drug release.
Main Methods:
- Niosomes were prepared using the thin-film hydration method.
- Formulations included aqueous dispersion, lyophilized powder, and lyophilized powder with cryoprotectant.
- Samples were stored at 5°C or 25°C/60% RH for 3 months, with subsequent analysis of drug leakage, particle size, zeta potential, and drug release.
Main Results:
- Niosomes provided sustained release of piroxicam with low drug leakage (1.56-6.63%).
- Particle size increased upon storage, while zeta potential remained consistent.
- Drug release profiles were similar across formulations, indicating increased rigidity over time.
Conclusions:
- Lyophilized niosomes stored at 5°C exhibited the best stability.
- Niosome rigidity increased with storage time, affecting drug release.
- Further research on cryoprotectants and lyophilization optimization is recommended for enhanced niosome stability.
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