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Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Parkinson Disease l: Introduction01:24

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Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
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Parkinson Disease ll: Pathophysiology01:24

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer Disease l: Introduction01:29

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Related Experiment Video

Updated: Apr 26, 2026

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

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Huntington's Disease - A Brief Historical Perspective.

Alice Wexler1

  • 1Center for the Study of Women, UCLA, Los Angeles, CA, USA. arwexler@ucla.edu

Journal of Huntington'S Disease
|July 25, 2014
PubMed
Summary
This summary is machine-generated.

Huntington's disease (HD) research has advanced significantly since the 1960s due to advocacy and scientific progress. While effective therapies are still developing, new treatments for this neurodegenerative disorder are nearing clinical application.

Keywords:
HDHereditary Disease FoundationHuntington'sHuntington's Disease Society of AmericaMarjorie GuthrieMilton Wexleradvocacyhistorylay association

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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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Last Updated: Apr 26, 2026

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
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Area of Science:

  • Neuroscience
  • Genetics
  • Medical History

Background:

  • Huntington's disease (HD) has a long history, recognized in the mid-19th century but lacking effective treatments, leading to families concealing the condition.
  • Grass-roots advocacy by HD families, alongside breakthroughs in Parkinson's disease treatment and the rise of molecular genetics and neuroscience, spurred increased research focus on HD starting in the late 1960s.

Observation:

  • Historically, physicians struggled to find therapies for Huntington's disease.
  • Patient advocacy and scientific advancements in related fields have been crucial in elevating HD research.

Findings:

  • Biomedical research into Huntington's disease has grown substantially.
  • Despite research progress, therapeutic interventions for HD are still in development, though closer to clinical reality.

Implications:

  • The growing body of research suggests a future with more effective treatments for Huntington's disease.
  • The establishment of dedicated resources like the Journal of Huntington's Disease aids in accelerating progress toward disease-altering interventions.