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Cellobiose: mannitol differential permeability in small bowel disease
S Hodges1, S P Ashmore, H R Patel
1Department of Child Health, University of Leicester.
Archives of Disease in Childhood
|June 1, 1989
Summary
The cellobiose:mannitol ratio test effectively detects small bowel mucosal damage. Elevated ratios indicate conditions like villous atrophy, anemia, and Crohn
Area of Science:
- Gastroenterology
- Clinical Diagnostics
- Biochemistry
Background:
- Assessing small bowel mucosal integrity is crucial for diagnosing various gastrointestinal disorders.
- Traditional diagnostic methods can be invasive or lack sensitivity.
Purpose of the Study:
- To evaluate the utility of the cellobiose and mannitol absorption test in identifying abnormal small bowel mucosal function.
- To determine if the urinary cellobiose:mannitol ratio can serve as a sensitive biomarker for mucosal integrity.
Main Methods:
- Patients with suspected small bowel mucosal dysfunction underwent oral administration of cellobiose and mannitol.
- Urinary excretion of both sugars was measured.
- The ratio of urinary cellobiose to mannitol was calculated.
Main Results:
- An increased urinary cellobiose:mannitol ratio was observed in patients with subtotal villous atrophy.
- Elevated ratios were also found in cases of iron deficiency anemia and small intestinal Crohn's disease.
- The test demonstrated sensitivity in detecting mucosal abnormalities.
Conclusions:
- The cellobiose:mannitol absorption test is a sensitive indicator of small bowel mucosal integrity.
- This non-invasive test can aid in the diagnosis of conditions affecting the small intestine.