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Related Experiment Videos

Flecainide toxicity.

G A Russell1, R P Martin

  • 1Department of Paediatric Cardiology, Royal Liverpool Children's Hospital.

Archives of Disease in Childhood
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Flecainide toxicity in an infant was linked to diet changes. Stopping milk feeds increased flecainide absorption, leading to dangerous ventricular tachycardia.

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Area of Science:

  • Pediatric Cardiology
  • Clinical Pharmacology

Background:

  • Atrioventricular re-entry tachycardia (AVRT) is a significant arrhythmia in infants.
  • Flecainide is an antiarrhythmic drug used to manage supraventricular tachycardias.

Observation:

  • An infant receiving flecainide for refractory AVRT experienced toxicity.
  • Ventricular tachycardia (VT) emerged when milk-based nutrition was replaced with dextrose feeds.

Findings:

  • Milk-based feeds appear to inhibit flecainide absorption.
  • Discontinuation of milk led to a surge in serum flecainide concentration.
  • This pharmacokinetic interaction precipitated flecainide-induced VT.

Implications:

  • Dietary components can significantly impact flecainide bioavailability in infants.
  • Careful consideration of nutritional intake is crucial during flecainide therapy.
  • This case highlights the need for monitoring drug absorption in relation to diet in pediatric patients.