Related Experiment Video
Updated: Apr 26, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis]
Guizuo Wang1, Yonghong Zhang, Xinming Xie
1Institute of Respiratory Medicine, Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.
Objective:
To systematically review whether statins can reduce the risk of infection and infection-related mortality.
Methods:
We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.
Results:
Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).
Conclusion:
Statins can significantly reduce the risk of infection but does not lower infection-related mortality.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Endocarditis III: Medical Management
Atherosclerosis III: Management

