Related Experiment Video
Updated: Feb 10, 2026
06:39
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
1.5K
Topical and systemic antimicrobial therapy for venous leg ulcers
Susan O'Meara1, Rachel Richardson2, Benjamin A Lipsky3
1School of Healthcare, Baines Wing, University of Leeds, England.
JAMA
|July 25, 2014
Summary
Systemic antibiotics show no clear benefit for venous leg ulcer healing. However, topical cadexomer iodine may improve healing compared to standard wound care for these chronic wounds.
Area of Science:
- Vascular Medicine
- Dermatology
- Infectious Disease
Background:
- Venous leg ulcers (VLUs) are chronic, debilitating wounds.
- Antimicrobial treatments are often considered for VLU management.
- Evidence on the efficacy of antimicrobial agents in VLU healing is limited.
Purpose of the Study:
- To evaluate the effectiveness of topical or systemic antimicrobial agents for venous leg ulcer healing.
- To compare antimicrobial treatments against usual care or alternative antimicrobial therapies.
Main Methods:
- Systematic review and meta-analysis of clinical trials.
- Inclusion of studies comparing antimicrobial agents (topical or systemic) with usual care or other antimicrobial agents.
- Assessment of ulcer healing as the primary outcome.
Main Results:
- Pooled data from underpowered studies could not establish or refute a link between systemic antibiotics and improved VLU healing.
- Topical cadexomer iodine demonstrated a potential association with better healing outcomes compared to usual care.
- Evidence for other topical or systemic antimicrobial agents was inconclusive.
Conclusions:
- Current evidence is insufficient to support or reject systemic antibiotic use for VLU healing.
- Topical cadexomer iodine shows promise as an effective treatment option for VLUs.
- Further high-quality research is needed to clarify the role of various antimicrobial agents in VLU management.
More Related Videos
Related Concept Videos
01:30Venous Thrombosis I: Introduction
478
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
478
01:28Antimicrobial Effectiveness
1.0K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.0K
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.4K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.4K
01:23Muscles that Move the Leg
5.4K
The movement of the legs is facilitated by numerous muscles located within the anterior, medial, and posterior compartments of the thigh.
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
5.4K
01:04Venous Return
12.5K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.5K
01:23Antimicrobial Proteins
14.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.5K