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Determinative developmental cell lineages are robust to cell deaths.

Jian-Rong Yang1, Shuxiang Ruan1, Jianzhi Zhang1

  • 1Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America.

Plos Genetics
|July 25, 2014
PubMed
Summary

Phenotypic robustness, crucial for life, is achieved through specific developmental cell lineage structures. These lineages minimize the impact of cell deaths, offering a new mechanism for developmental stability and evolution.

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Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Cellular biology

Background:

  • Phenotypic robustness is essential for life facing environmental and genetic challenges.
  • Development is recognized as key to robustness, but mechanisms remain unclear.

Purpose of the Study:

  • To investigate the role of determinative cell lineages in phenotypic robustness.
  • To uncover the structural features of cell lineages contributing to robustness.

Main Methods:

  • Analysis of determinative cell lineages in two protostomes and one deuterostome.
  • Comparative study of lineage topology, cell type clonality, and developmental timing.
  • Simple simulations of cell lineage evolution under random cell death scenarios.

Main Results:

  • Determinative cell lineages exhibit structures that limit the impact of cell deaths on organismal composition.
  • Key features include lineage shallowness, specific topology, early appearance of rare cells, and non-clonality.
  • Simulations suggest these features may be adaptive responses to developmental cell death.

Conclusions:

  • Determinative cell lineages possess general organizing principles that confer phenotypic robustness.
  • This study reveals a novel mechanism for phenotypic robustness with implications for development and evolution.