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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Increased GH response to GHRH in normal tall men
M Batrinos1, E Georgiadis, C Panitsa-Faflia
1Department of Pharmacology, Athens Medical School, Athens Goudi, Greece.
Clinical Endocrinology
|January 1, 1989
Summary
Tall adult males exhibit enhanced pituitary responsiveness to growth hormone-releasing hormone (GHRH). This heightened growth hormone (GH) secretion may contribute to variations in population height.
Area of Science:
- Endocrinology
- Human Physiology
- Growth Biology
Background:
- Growth hormone (GH) secretion is crucial for individual growth.
- Population height variations may be linked to differences in GH secretory capacity.
Purpose of the Study:
- To investigate the role of GH secretory capacity in determining height variations.
- To compare GH response to GHRH in tall and average-height adult males.
Main Methods:
- Studied 20 tall (190.8 cm) and 17 average-height (173.8 cm) adult males.
- Administered synthetic GHRH (1-29) NH2 and measured GH levels.
- Compared basal and stimulated GH concentrations, and integrated response curves.
Main Results:
- Tall subjects showed a tendency towards higher basal GH levels.
- GH rise after GHRH administration was significantly greater in tall subjects.
- Integrated GH response curves were significantly larger in tall individuals (P < 0.01).
Conclusions:
- Tall individuals exhibit enhanced pituitary responsiveness to GHRH.
- This enhanced GH secretion may be a factor in their increased stature.
- Further research is needed to confirm if this responsiveness is chronic.
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