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In vitro activity of cefoperazone-sulbactam combinations against cefoperazone-resistant clinical bacterial isolates
G M Eliopoulos1, K Klimm, M J Ferraro
1Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
Abstract:
From July 1987 to January 1988, 452 cefoperazone-resistant bacterial isolates were identified among strains subjected to routine susceptibility testing in a clinical microbiology laboratory. The 452 isolates were tested for susceptibility to cefoperazone, sulbactam, and a 2:1 combination of these drugs by agar dilution techniques. The greatest benefit of the cefoperazone-sulbactam combination was noted against Bacteroides spp. and Acinetobacter spp. The combination demonstrated clinically significant synergism against approximately 20% of strains of Pseudomonas aeruginosa.
Insights
The cefoperazone-sulbactam combination showed effectiveness against resistant bacteria like Bacteroides and Acinetobacter. Synergistic effects were observed in some Pseudomonas aeruginosa strains.
Area of Science:
- Microbiology
- Clinical Pharmacology
Background:
- Cefoperazone resistance is a growing concern in clinical settings.
- Routine susceptibility testing identifies resistant bacterial isolates.
Purpose of the Study:
- To evaluate the efficacy of a cefoperazone-sulbactam combination against cefoperazone-resistant bacteria.
- To identify specific bacterial species that benefit most from this combination therapy.
Main Methods:
- Agar dilution techniques were used to test bacterial susceptibility.
- 452 cefoperazone-resistant isolates were analyzed for their response to cefoperazone, sulbactam, and their combination.
Main Results:
- The cefoperazone-sulbactam combination demonstrated significant activity against Bacteroides spp. and Acinetobacter spp.
- Clinically significant synergism was observed in approximately 20% of Pseudomonas aeruginosa strains tested.
Conclusions:
- The cefoperazone-sulbactam combination offers a potential therapeutic option for infections caused by certain resistant bacteria.
- Further investigation into the synergistic mechanisms against Pseudomonas aeruginosa is warranted.